Can non-pharmacological interventions prevent relapse in adults who have recovered from depression? A systematic review and meta-analysis of randomised controlled trials

摘要: Abstract Objective To identify studies of non-pharmacological interventions provided following recovery from depression, and to evaluate their efficacy in preventing further episodes. Method We identified relevant randomised controlled trials searching MEDLINE, Embase, PsycINFO, CENTRAL, ProQuest, reference citation lists, contacting study authors. conducted a meta-analysis relapse outcomes. Results There were 29 eligible trials. 27 two-way comparisons including 2742 participants included the primary analysis. At 12 months cognitive–behavioural therapy (CBT), mindfulness-based cognitive (MBCT), interpersonal psychotherapy (IPT) associated with 22% reduction compared controls (95% CI 15% 29%). The effect was maintained at 24 months for CBT, but not IPT despite ongoing sessions. no 24-month MBCT data. A key area heterogeneity differentiating these groups prior acute treatment. Other psychological therapies service-level programmes varied efficacy. Conclusion implications Psychological may prolong person has achieved through use medication or therapy. Although there evidence that is effective, it largely tested medication, so its less clear. only IPT. Further exploration sequencing needed. Systematic review registration number PROSPERO 2011:CRD42011001646