Genetic test reporting enhances understanding of risk information and acceptance of prevention recommendations compared to family history-based counseling alone

摘要: It is unknown whether or why genetic test reporting confers benefits in the understanding and management of cancer risk beyond what patients learn from counseling based on family history. A prospective nonexperimental control group study compared participants melanoma-prone families who underwent CDKN2A/p16 (p16) testing (27 carriers, 38 noncarriers) to equivalently known not carry a deleterious p16 mutation (31 no-test controls). All received equivalent concerning elevated lifetime melanoma corresponding recommendations for prevention screening. Both immediately 1 month after counseling, receiving result reported greater their risk, decreased derogation information, personal applicability than controls. Decreased information predicted further increases later. Results suggest unique promoting acceptance about hereditary its management.