Mechanisms of Antineoplastic Action of Somatostatin Analogs

摘要: Over the past decade, impressive antineoplastic activity of somatostatin analogs has been demonstrated in many tumor models. More recent research provided information regarding mechanisms underlying antiproliferative and apoptosis-inducing actions these compounds. These include both 'direct' that are sequellae binding to receptors present on neoplastic cells 'indirect' related effects host. The upregulation intracellular tyrosine phosphatase triggered by ligands type II receptor received considerable attention as a direct mechanism, not only because this is converse kinase associated with peptide mitogen receptors, but also frequently expressed common human neoplasms, including breast cancer. potential importance indirect action analogs, such alterations host insulin-like growth factor physiology, emphasized vivo compounds against receptor-negative neoplasms. Clinical efficacy favorable toxicity profile treatment relatively uncommon conditions acromegaly neuroendocrine tumors have already demonstrated. Preclinical data now sufficient justify controlled clinical trials breast, prostate, pancreatic development monthly depot formulations will facilitate evaluation for other indications.