The role of high-density lipoprotein cholesterol in atherothrombosis.

摘要: Despite considerable progress in the development of new therapies to control atherosclerosis and its complications, coronary heart disease (CHD) remains number one cause death Western world. While low high-density lipoprotein (HDL) has been associated with increased risk for CHD, raising HDL reduce yet be accepted as a standard therapeutic strategy. Currently available drugs that raise (e.g., nicotinic acid, fibric acid derivatives, peroxisome proliferator-activated receptor agonists, statins) also affect low-density (LDL) other lipid constituents, making independent interpretation their HDL-raising effect difficult tease apart. Nevertheless, basic science studies suggest multiple beneficial effects, current efforts develop pharmacologic products potent HDL-elevating effects may herald day when elevation becomes part management atherosclerotic diseases.