Zinc and Skin Disorders.
作者： , , ,
DOI: 10.3390/NU10020199
关键词: Subcutaneous tissue 、 Biotin deficiency 、 Epidermis 、 Acrodermatitis enteropathica 、 Intestinal epithelium 、 Endocrinology 、 Epidermodysplasia verruciformis 、 Chemistry 、 Dermis 、 Internal medicine 、 Necrolytic migratory erythema
摘要: The skin is the third most zinc (Zn)-abundant tissue in body. consists of epidermis, dermis, and subcutaneous tissue, each fraction composed various types cells. Firstly, we review physiological functions Zn transporters these Several human disorders accompanied with manifestations are caused by mutations or dysregulation transporters; acrodermatitis enteropathica (Zrt-, Irt-like protein (ZIP)4 intestinal epithelium possibly epidermal basal keratinocytes), spondylocheiro dysplastic form Ehlers-Danlos syndrome (ZIP13 dermal fibroblasts), transient neonatal deficiency (Zn transporter (ZnT)2 secretory vesicles mammary glands), epidermodysplasia verruciformis (ZnT1 keratinocytes). Additionally, acquired deeply involved development some diseases related to nutritional deficiencies (acquired enteropathica, necrolytic migratory erythema, pellagra, biotin deficiency), alopecia, delayed wound healing. Therefore, it important associate existence manifestations.
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