Systematic review and meta-analysis of the prognostic significance of microRNAs related to metastatic and EMT process among prostate cancer patients

摘要: The ability of tumor cells to spread from their origin place and form secondary foci is determined by the epithelial–mesenchymal transition process. In epithelial tumors such as prostate cancer (PCa), loss intercellular interactions can be observed a change in expression polarity proteins. Epithelial acquire migrate, what leads formation distal metastases. recent years, interest miRNA molecules potential future treatment options has increased. microenvironment, miRNAs have regulate signal transduction pathways, where they act suppressors or oncogenes. MiRNAs are secreted cells, changes levels closely related progression, including transition. These offer new diagnostic therapeutic possibilities. Therapeutics which make use synthesized RNA fragments mimic block affected PCa, may lead inhibition progression even disease re-emission. Based on appropriate qualification criteria, we conducted selection process identify scientific articles describing relation PCa patients. studies were published English Pubmed, Scopus Web Science before August 08, 2019. Hazard ratios (HRs) 95% confidence intervals (CI) well total Gleason score used assess concordance between presence A 13 included our meta-analysis, representing 1608 patients 15 molecules. Our study clarifies relationship clinicopathological features aberrant several complex mechanism involvement induction promotion metastatic PCa.