Soluble interleukin-2 receptor, intercellular adhesion molecule-1 and interleukin-10 serum levels in patients with melanoma
作者： M D Boyano , M D Garcia-Vázquez , T López-Michelena , J Gardeazabal , J Bilbao
关键词: Melanoma 、 Survival analysis 、 Metastasis 、 Cytokine 、 Gastroenterology 、 Interleukin 10 、 Internal medicine 、 Risk factor 、 Interleukin 2 、 Intercellular Adhesion Molecule-1 、 Medicine 、 Immunology
摘要: Serum soluble interleukin-2 receptor (sIL-2R), intercellular adhesion molecule-1 (sICAM-1) and interleukin-10 (IL-10) have each been reported as useful markers for melanoma progression. To evaluate the clinical relevance of these three markers, we simultaneously analysed their serum levels in patients with melanoma. A longitudinal study a 3-year follow-up was performed different stages disease were considered. Mean values sIL-2R significantly higher than normal controls all correlated The prognosis > 529 U/ml poorer < U/ml. Levels sICAM-1 also elevated patients, specially at time metastatic disease. IL-10 more frequently detectable that developed metastasis during follow-up, those undetected levels. Statistical analysis based on Logistic Cox regression models showed only sex, stage value are factors associated Moreover, high could be risk factor malignant progression © 2000 Cancer Research Campaign
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