Ethanol: an enhancer of major histocompatibility complex antigen expression.
作者： Leslie J. Parent , Rachel Ehrlich , Lou Matis , Dinah S. Singer
DOI: 10.1096/FASEBJ.1.6.3678702
关键词: Antigen processing 、 Gene expression 、 Biology 、 MHC class I 、 Antigen 、 Major histocompatibility complex 、 CD8 、 Biochemistry 、 Cell culture 、 Cell biology 、 MHC restriction
摘要: Ethanol enhances expression of cell surface class I major histocompatibility complex (MHC) antigens in a variety lines; up to an eightfold increase is observed embryonic line. In ethanol-treated L cells, increased MHC occurs with concomitant steady-state RNA levels. This effect promoter dependent and restricted, because not all gene products are elevated. The effective ethanol concentration (1%) physiologically attainable, leading speculations about the role elevated alcohol-related diseases.
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