Influence of T-calcium channel blocker treatment on deterioration of renal function in chronic kidney disease.
作者： Kiyotsugu Omae , Tetsuya Ogawa , Kosaku Nitta
DOI: 10.1007/S00380-008-1125-Y
关键词: Medicine 、 Probucol 、 Urology 、 Calcium channel blocker 、 Kidney disease 、 Pharmacology 、 Prednisolone 、 Polycystic kidney disease 、 Single Center 、 Renal function 、 Proteinuria
摘要: Some calcium channel blockers (CCBs) have renoprotective effects. Our aim was to compare the effects of different subclasses CCBs on deterioration renal function in chronic kidney disease (CKD). This is a prospective, observational cohort study single center. The subjects were 107 nondiabetic CKD patients. rate estimated glomerular filtration (ΔeGFR) calculated by [last visit eGFR — baseline eGFR/follow-up duration]. Multivariate analysis performed using change urinary protein (ΔUP) and ΔeGFR during follow-up as response variables. CCB L-type 76 patients, T- 28 nondihydropyridines 6 Multiregression indicated that higher proteinuria (UP) use angiotensin-converting enzyme inhibitors (ACEIs) angiotensin II receptor associated with decrease UP, while CCBs, prednisolone, probucol increase UP. ACEIs diuretics good outcome terms ΔeGFR, whereas glomerulonephritis, polycystic disease, UP poor outcome. It suggested among other may improve patients function.
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