Source of the Acetyl Group in Acetylcholine

摘要: It is an ill wind that blows no one any good. The advent of the ill-fated Nazi regime in early thirties wafted many scientists from Germany into America and United Kingdom. Among those who found hospitality my laboratory a mental hospital Cardiff, Wales, was whose major qualification for biochemical prowess his unexpected skill estimating acetylcholine (ACh) by leech assay technique. He came to me about 1934 I decided there then carry out studies on ACh formation isolated brain. At time were very few laboratories world carrying systematic brain related function. Perhaps nearest work these lines, outside our laboratory, Peters colleagues (27) Oxford action vitamin B1 pyruvate oxidation polyneuritic pigeon preparations. Some earlier than this we had found, cerebral (30) glucose, lactate are readily oxidized tissue vitro that, at normal physiological concentrations, glucose fuel vitro. known time, contains ACh-like substance fact, values order 2 nmol/g wet wt been quoted content brains dog, cat guinea pig.