Comparative analysis of primary hepatocellular carcinoma with single and multiple lesions by iTRAQ-based quantitative proteomics
作者： Xiaohua Xing , Yao Huang , Sen Wang , Minhui Chi , Yongyi Zeng
DOI: 10.1016/J.JPROT.2015.08.007
关键词: Signal transduction 、 Bioinformatics 、 Proteomics 、 Cancer research 、 Gene expression profiling 、 Potential biomarkers 、 Carcinogenesis 、 Proteome 、 Biology 、 Quantitative proteomics 、 Hepatocellular carcinoma
摘要: In clinical practices, the therapeutic outcomes and prognosis of hepatocellular carcinoma (HCC) patients with different tumor numbers after surgery are very different; however, underlying mechanisms tumorigenesis development HCC still not well understood. Here, we systematically compared overall proteome profiles between primary single multiple lesions using iTRAQ-based quantitative proteomics approach. We identified that 107 330 proteins were dysregulated in tissue (MC group) a lesion (SC group), their non-cancerous (MN SN groups) respectively. The MC group concentrated UBC signaling pathway NFκB pathway, but SC more ERK pathway. These information revealed there might be molecular lesions. Furthermore, HSD17B13 only down-regulated while HK2 up-regulated among these proteins. Therefore, protein potential biomarkers for
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