Poly(MAA-co-AN) hydrogels with improved mechanical properties for theophylline controlled delivery.

摘要: A hydrophobically improved copolymer hydrogel was constructed and developed based on methacrylic acid (MAA) acrylonitrile (AN) monomers. The swelling investigations indicated that the hydrogels were highly sensitive to pH ionic strength of surrounding environment. ratios gels in stimulated intestinal fluids (SIF, 7.4) higher than those gastric (SGF, 1.4), followed a non-Fickian Fickian diffusion mechanism, respectively. results match well with scanning electron microscopy observations showing mesh sizes SGF are larger more patulous SIF. It is believed phenomena concerned electrostatic repulsion originating from formation dissociation carboxyl groups, as charge screening effect cations leading reduction osmotic pressure. dynamic mechanical analyzer revealed addition hydrophobic AN units notably compression properties control sample. With an increase concentrations, ability for copolymers resist deformation enhanced distilled water strains have almost same values SIF environments. Differential calorimetry used analyze state determine amounts freezing non-freezing water. controlled release examination theophylline model drug showed rate faster or SGF. introduction decreased rates both SGF, variation behavior AN-modified P(MAA-co-AN) deviates mechanism. This expected be excellent material oral release.