Clinical characteristics of disseminated intravascular coagulation in patients with solid and hematological cancers.

摘要: Malignant disease can be complicated by disseminated intravascular coagulation (DIC). DIC is defined as systemic triggering of (resulting in fibrin clot formation) and concurrent depletion clotting factors platelets (increasing the risk hemorrhage). The clinical presentation patients with cancer has usually a less fulminant than that may accompany other underlying disorders, such sepsis trauma. A more insidious, but also protracted, diffuse activation proceed without any symptom. Ultimately this lead to deficiency hemorrhage (often at site tumor or metastases) first symptom indicating presence DIC. An alternative thrombosis, ranging from overt venous thrombo-embolism microvascular thrombotic microangiopathy. therapeutic foundation management condition some cases supportive interventions, specifically targeting hemostatic system needed.