Intrathecal lidocaine prevents cardiovascular collapse and neurogenic pulmonary edema in a rat model of acute intracranial hypertension.

摘要: UNLABELLED Sympathetic hyperactivity during sudden intracranial hypertension leads to cardiovascular instability, myocardial dysfunction, and neurogenic pulmonary edema. Because spinal anesthesia is associated with sympatholysis, we investigated the protective effects of intrathecal lidocaine in a rodent model. Halothane-anesthetized rats were given 10-microL injection saline (n = 10) or 1% 6). A subdural balloon catheter was inflated for 60 s produce hypertension. Hemodynamics monitored, hearts lungs harvested histological examination. In Saline versus Lidocaine-Treated rats, peak mean arterial blood pressure inflation 115 +/- 4 mm Hg 78 8 (P < 0.05), 30 min after deflation 47 2 67 3 lung weight 1.54 0.03 g 1.41 0.04 respectively. Cardiac dysrhythmias electrocardiographic changes more frequent Saline-Treated group 0.05). had extensive, hemorrhagic edema, whereas only patchy areas abnormality. Histological myocardium rare, no difference found between two groups. We conclude that prevents collapse edema rat model acute IMPLICATIONS inflation, prevented Descending neural pathways are involved development cardiopulmonary complications