Power Spectral Analysis of Heart Rate Variation in Diabetic Patients With Neuropathic Foot Ulceration

摘要: OBJECTIVE To evaluate the relationship between diabetic autonomic neuropathy and neuropathic foot ulceration, we used power spectral analysis (PSA) of heart rate variation, which provides accurate simultaneous quantification parasympathetic sympathetic activities, to assess function in patients. RESEARCH DESIGN AND METHODS We studied 55 NIDDM patients including 10 without neuropathy, 23 with no history 22 ulceration. performed PSA 100 R-R intervals at rest analyzed results by fast Fourier transformation. RESULTS The low frequency (LF) power, reflects activity, high (HF) (vagal) were inversely correlated duration diabetes fasting plasma glucose (FPG) levels. By multiple regression analysis, FPG remained significant influence on both LF HF powers. powers positively motor nerve conduction velocity (MCV) sensory (SCV) upper lower limbs coefficient variation intervals. significantly reduced ulceration compared neuropathy. Although median MCV SCV similar decreased There was difference value LF:HF ratio, an index sympathovagal balance, among three subgroups. observed a positive correlation all subjects; however, not subgroups CONCLUSIONS These showed that have greater impairment indexes activity obtained than whereas present velocities.