The rhodium-promoted guerbet reaction: Part II. Secondary alcohols and methanol as substrates
作者： Patrick L. Burk , Roy L. Pruett , Kathryn S. Campo
DOI: 10.1016/0304-5102(85)85013-6
关键词: Aldol condensation 、 Chemistry 、 Catalysis 、 Alcohol 、 Organic chemistry 、 Methanol 、 Primary alcohol 、 Condensation reaction 、 Guerbet reaction 、 Ketone
摘要: Abstract The scope of the low temperature rhodium-promoted Guerbet alcohol condensation reaction has been extended to include methyl secondary substrates. proceeds via ketonic intermediates with new C-C bond forming in an aldol step. Unsymmetrical substrates gave product distributions which mirrored those expected from ketone self-condensations. investigation also revealed that methanol could serve both as a solvent for and substrate. A cross-condensation between primary β-methyl carbinol.
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