Memory lapses in graft‐versus‐host disease

摘要: "Faster, better, more'' is the conventional benchmark used to define responses of memory T cells when compared with their naive counterparts. In this issue European Journal Immunology, Mark and Warren Shlomchik colleagues [Eur. J. Immunol. 2011. 41: 2782-2792] make intriguing observation that murine CD4(+) T-cell populations enriched for alloreactive precursors are fully capable rejecting allogeneic skin grafts but yet incapable inducing significant graft-versus-host disease. These observations add emerging concept development more nuanced complex than predicted by models. particular, data suggest it may be just as important consider what or effector have "lost'' in transition memory.