R1 and R2 * changes in the human placenta in response to maternal oxygen challenge.

摘要: PURPOSE: Pregnancy complications such as preeclampsia and fetal growth restriction are sometimes thought to be caused by placental abnormalities associated with reduced oxygenation. Oxygen-enhanced MRI (R(1) contrast) BOLD (R(2) * have the potential noninvasively investigate this oxygen environment at a range of gestational ages. METHODS: Scanning was carried out 1.5 T under maternal air breathing in single slice 14 healthy pregnant subjects ages 21-37 weeks. We report R(1) changes using respiratory-triggered inversion recovery-turbo spin-echo sequence, which is sensitive PO(2) , R(2) breathhold multiple gradient-recalled echo sequence saturation. RESULTS: Significant increases (P < 0.005, paired t-test) decreases 0.0001, between were demonstrated. ?R(1) decreased age 0.0005, r = -0.835, Pearson correlation test). No significant effect on change observed. CONCLUSION: The results demonstrate feasibility non-invasive investigation oxygenation sensitivity oxygen-enhanced age. techniques provide unique noninvasive biomarkers compromised pregnancies. Magn Reson Med, 2012. � 2012 Wiley Periodicals, Inc.