Physiological Functions of Plasminogen Activation: Effects of Gene Deficiencies in Humans and Mice

摘要: Exhaustive analysis of humans and mice with genetic deficiencies in plasminogen, plasminogen activators, plasmin inhibitor, activator inhibitors have yielded fundamental new insights into both the mechanisms activation physiological functions system. At least five different pathways for are operative vivo, these display a remarkable functional redundancy. Plasminogen as well components that govern inhibition system dispensable development. However, cleavage fibrin other extracellular substrates by is critical postnatal remodeling repair multiple epithelial mesenchymal tissues. As consequence, life without associated high morbidity mortality due to progressive multiorgan damage. Conversely, activators not only markedly accelerate tissue but also result lifelong bleeding predisposition premature dissolution.