Proteomics reveals the effects of sustained weight loss on the human plasma proteome.
作者： Philipp E Geyer , Nicolai J Wewer Albrechtsen , Stefka Tyanova , Niklas Grassl , Eva W Iepsen
关键词: Proteome 、 Weight loss 、 Biology 、 Blood proteins 、 Proteomics 、 Apolipoprotein B 、 Internal medicine 、 Adiponectin 、 Bioinformatics 、 Insulin resistance 、 Endocrinology 、 Metabolic syndrome
摘要: Sustained weight loss is a preferred intervention in wide range of metabolic conditions, but the effects on an individual's health state remain ill-defined. Here, we investigate plasma proteomes cohort 43 obese individuals that had undergone 8 weeks 12% body followed by year maintenance. Using mass spectrometry-based proteome profiling, measured 1,294 proteomes. Longitudinal monitoring revealed individual-specific protein levels with wide-ranging losing reflected 93 significantly affected proteins. The adipocyte-secreted SERPINF1 and apolipoprotein APOF1 were most regulated fold changes -16% +37%, respectively (P < 10-13), entire family showed characteristic differential regulation. Clinical laboratory parameters are proteome, eight proteins correlated better insulin resistance than known marker adiponectin. Nearly all study participants benefited from regarding ten-protein inflammation panel defined proteomics data. We conclude profiling broadly evaluates monitors diseases.
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