Mean platelet volume and high-residual platelet reactivity in patients receiving dual antiplatelet therapy with clopidogrel or ticagrelor

摘要: Objective: High on-treatment platelet reactivity (HRPR) is associated with a two- to ninefold increased risk of recurrent ischemic events among patients receiving dual antiplatelet therapy (DAPT) for coronary artery disease. However, its determinants are still poorly understood. The aim the present study was assess impact mean volume (MPV) on in DAPT after an acute syndrome or PCI.Methods: Patients treated (acetylsalicylic acid [ASA] and clopidogrel ticagrelor) were scheduled function assessment at 30 – 90 days post-discharge. By whole blood impedance aggregometry, HRPR considered ASPI test > 862 aggregation units (AU)*min (for ASA) ADP values ≥ 417 AU*min ADP-antagonists).Results: Our population represented by total 487 DAPT, divided according MPV tertiles (< 10.4 fl; 11.29 11.3 fl). Larger-sized platelets use statins (p < 0.001)...