The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR.
作者： Nasha Nassoury , Daniel A. Blasiole , Angie Tebon Oler , Suzanne Benjannet , Josée Hamelin
DOI: 10.1111/J.1600-0854.2007.00562.X
关键词: Cell biology 、 Biology 、 Endocytic cycle 、 LDL receptor 、 Proprotein convertase 、 Clathrin 、 Endosome 、 PCSK9 、 Molecular biology 、 Endoplasmic reticulum 、 Golgi apparatus
摘要: … One involves binding to the mannose-6-phosphate receptor (MPR) in the trans Golgi network (TGN) or at the cell surface followed by its targeting to endosomes, as occurs with …
sci-hub.se 参考文章(46)
V Esser, D W Russell, Transport-deficient mutations in the low density lipoprotein receptor: alterations in the cysteine-rich and cysteine-poor regions of the protein block intracellular transport Journal of Biological Chemistry. ,vol. 263, pp. 13276- 13281 ,(1988) , 10.1016/S0021-9258(18)37701-9
D W Russell, M S Brown, J L Goldstein, Different combinations of cysteine-rich repeats mediate binding of low density lipoprotein receptor to two different proteins. Journal of Biological Chemistry. ,vol. 264, pp. 21682- 21688 ,(1989) , 10.1016/S0021-9258(20)88240-4
J E Murphy-Ullrich, L G Westrick, J D Esko, D F Mosher, Altered metabolism of thrombospondin by Chinese hamster ovary cells defective in glycosaminoglycan synthesis. Journal of Biological Chemistry. ,vol. 263, pp. 6400- 6406 ,(1988) , 10.1016/S0021-9258(18)68799-X
Jonathan C. Cohen, Marek Kimmel, Andrzej Polanski, Helen H. Hobbs, Molecular mechanisms of autosomal recessive hypercholesterolemia. Current Opinion in Lipidology. ,vol. 14, pp. 121- 127 ,(2003) , 10.1097/00041433-200304000-00002
Jennifer Lippincott-Schwartz, Lydia Yuan, Christopher Tipper, Myléne Amherdt, Lelio Orci, Richard D. Klausner, Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic Cell. ,vol. 67, pp. 601- 616 ,(1991) , 10.1016/0092-8674(91)90534-6
Weijun Jin, Ilia V. Fuki, Nabil G. Seidah, Suzanne Benjannet, Jane M. Glick, Daniel J. Rader, Proprotein Covertases Are Responsible for Proteolysis and Inactivation of Endothelial Lipase Journal of Biological Chemistry. ,vol. 280, pp. 36551- 36559 ,(2005) , 10.1074/JBC.M502264200
Majambu MBIKAY, Nabil G. SEIDAH, Michel CHRÉTIEN, Neuroendocrine secretory protein 7B2: structure, expression and functions. Biochemical Journal. ,vol. 357, pp. 329- 342 ,(2001) , 10.1042/BJ3570329
Jaap Twisk, Donald L. Gillian-Daniel, Angie Tebon, Lin Wang, P. Hugh R. Barrett, Alan D. Attie, The role of the LDL receptor in apolipoprotein B secretion. Journal of Clinical Investigation. ,vol. 105, pp. 521- 532 ,(2000) , 10.1172/JCI8623
Fangtian Huang, Anastasia Khvorova, William Marshall, Alexander Sorkin, Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference. Journal of Biological Chemistry. ,vol. 279, pp. 16657- 16661 ,(2004) , 10.1074/JBC.C400046200
Lin Guo, June R. Eisenman, Rajeev M. Mahimkar, Jacques J. Peschon, Raymond J. Paxton, Roy A. Black, Richard S. Johnson, A Proteomic Approach for the Identification of Cell-surface Proteins Shed by Metalloproteases Molecular & Cellular Proteomics. ,vol. 1, pp. 30- 36 ,(2002) , 10.1074/MCP.M100020-MCP200