Protein-Energy Malnutrition Delays Small-Intestinal Recovery in Neonatal Pigs Infected with Rotavirus

摘要: Infectious diarrheal diseases and protein-energy malnutrition (PEM) are major causes of child morbidity mortality worldwide. In the present study, PEM was superimposed on rotavirus infection in neonatal pigs to simulate chronic small intestinal stress malnourished infants with viral gastroenteritis. Two-day-old cesarean-derived (n = 39) were allotted three treatment groups: 1) noninfected, full-fed; 2) infected, 3) malnourished. Two days postinfection, severe diarrhea weight loss (11%) accompanied by reductions villus height (60%) lactase activity (78%) increased crypt depth (32%) infected full-fed compared noninfected (P < 0.05). Malnutrition blunted 0.05) increases elicited rotavirus. By 9 d body 59% less, remained lower (50%), greater (62%) However, began clear full-fed, but not pigs. Plasma insulin-like growth factor-I (IGF-I) reduced 68% 19% infected-malnourished Sixteen had recovered from rotaviral infection; however, pigs, stasis persisted, plasma IGF-I, alkaline phosphatase Overall, prolonged delayed small-intestinal recovery, indicating that nutritional status during is essential for recovery enteritis.