Cardiovascular, neurological, and inflammatory complications of obesity hypoventilation syndrome

摘要: Abstract Obesity hypoventilation syndrome (OHS) is a systemic disease with negative consequences that extend beyond the respiratory system. These patients have high prevalence of cardiovascular disease, pulmonary hypertension, neurocognitive dysfunction, hypersomnia, metabolic disorders, and elevated inflammatory markers. They usually significant functional limitations despite normal cardiac index evidence suggesting deranged hemodynamic profile as major cause. Other factors contribute to this problem are obesity-related heart failure preserved ejection fraction, right ventricular overload, left disease. Positive airway pressure therapy can improve gas exchange abnormalities, repercussions, capacity. The challenge timely diagnosis requires suspicion. It still an underdiagnosed