Clonidine GH stimulation test to differentiate MSA from idiopathic late onset cerebellar ataxia: a prospective, controlled study.

摘要: Despite the consensus criteria for multiple system atrophy (MSA), diagnosis of MSA cerebellar type (MSA-C) may be difficult in early stage disease. There are several differential diagnoses including idiopathic late-onset ataxias (ILOCA) and it is often necessary to wait clinical worsening so that can met. Our aim was assess efficacy clonidine growth hormone test (CGH test) distinguish MSA-C from ILOCA Within our cohort sporadic, progressive ataxia, group patients meeting possible or probable compared group. Clinical paraclinical examination CGH were repeated during prospective follow-up. Eighty-six recruited, 42 44 with a mean follow-up 33 months. At inclusion visit, CHG pathological 31% 18.2% (p = 0.35). During follow-up, 52.4% had test, while only 20.5% (p < 0.01). sensitivity 69.1% specificity 68.2%, (p < 0.001) patients; allows three quarters cases, if negative, rule out (negative predictive value 75%, p = 0.0014). This prospective, controlled study showed could helpful practice differentiate