Assessment of the genotoxic and carcinogenic risks of p-nitrophenol when it is present as an impurity in a drug product
作者： G. Eichenbaum , M. Johnson , D. Kirkland , P. O’Neill , S. Stellar
DOI: 10.1016/J.YRTPH.2009.05.018
关键词: Clastogen 、 Micronucleus test 、 Reference dose 、 Drug Impurity 、 Genotoxicity 、 Micronucleus 、 In vivo 、 Carcinogen 、 Chemistry 、 Pharmacology
摘要: … p-Nitrophenol (PNP) is a synthetic chemical that is used as a starting material for pharmaceutical products and dyes and as a fungicide. As such, the toxicity and safety profile of PNP …
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