Maximum-likelihood criterion and single-molecule detection
作者： Jörg Enderlein
DOI: 10.1364/AO.34.000514
关键词: Fourier transform 、 Photon counting 、 Molecular physics 、 Light intensity 、 Physics 、 Molecule 、 Optics 、 Maximum likelihood criterion 、 Fluorescence 、 Diffusion (business) 、 Photon
摘要: The maximum-likelihood criterion is shown to be a powerful method for analyzing fluorescence-detection data with small signal-to-noise ratios. A probability study of the supposed single-molecule detection experiment presented that takes into account photokinetics molecule detected, its diffusion, and laser-beam geometry. Furthermore, efficiency time-integrated time-correlated single-photon counting methods are studied compared.
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