Identification of genome-wide significant shared genomic segments in large extended Utah families at high risk for completed suicide
作者： Zhe Yu , Nancy William , Sujan C. Das , Sheila E. Crowell , Danli Chen
DOI: 10.1101/195644
关键词: Biology 、 Identification (biology) 、 Medical examiner 、 Demography 、 Genome 、 Extended family 、 Completed Suicide 、 Cause of death 、 Family aggregation 、 Population Database
摘要: Suicide is the 10th leading cause of death in US. While environment has undeniable impact, evidence suggests that genetic factors play a major role completed suicide. We have >4,500 DNA samples from suicides through collaboration with Utah Medical Examiner. linked records these cases to Population Database which includes multi-generation genealogies, demographic data, and medical information on over 8 million individuals. This linking resulted extended families (7-9 generations) significant familial risk Familial aggregation across distant relatives minimizes effects shared environment, provides more genetically homogeneous groups, magnifies risks repetition. analyzed 215 suicide 43 our largest high-risk identified 16 regions genome-wide significance 10 families. Of 163 genes regions, 25% were associated psychiatric risk. also found 13 suggestive where region overlaps >1 family (p-values 4.63E-09
sci-hub.st 参考文章(81)
Sir Ronald Aylmer Fisher, Statistical Methods for Research Workers ,(1925)
Richard A. Kerber, Method for calculating risk associated with family history of a disease Genetic Epidemiology. ,vol. 12, pp. 291- 301 ,(1995) , 10.1002/GEPI.1370120306
Andreas Menke, Katharina Domschke, Darina Czamara, Torsten Klengel, Johannes Hennings, Susanne Lucae, Bernhard T Baune, Volker Arolt, Bertram Müller-Myhsok, Florian Holsboer, Elisabeth B Binder, Genome-wide association study of antidepressant treatment-emergent suicidal ideation. Neuropsychopharmacology. ,vol. 37, pp. 797- 807 ,(2012) , 10.1038/NPP.2011.257
Holly K. Tabor, Neil J. Risch, Richard M. Myers, Candidate-gene approaches for studying complex genetic traits: practical considerations. Nature Reviews Genetics. ,vol. 3, pp. 391- 397 ,(2002) , 10.1038/NRG796
Peter McGuffin, Andrej Marušič, Anne Farmer, What can psychiatric genetics offer suicidology Crisis-the Journal of Crisis Intervention and Suicide Prevention. ,vol. 22, pp. 61- 65 ,(2000) , 10.1027//0227-5910.22.2.61
N.L. Pedersen, A. Fiske, Genetic influences on suicide and nonfatal suicidal behavior: Twin study findings European Psychiatry. ,vol. 25, pp. 264- 267 ,(2010) , 10.1016/J.EURPSY.2009.12.008
Yukinori Okada, Chikashi Terao, Katsunori Ikari, Yuta Kochi, Koichiro Ohmura, Akari Suzuki, Takahisa Kawaguchi, Eli A Stahl, Fina A S Kurreeman, Nao Nishida, Hiroko Ohmiya, Keiko Myouzen, Meiko Takahashi, Tetsuji Sawada, Yuichi Nishioka, Masao Yukioka, Tsukasa Matsubara, Shigeyuki Wakitani, Ryota Teshima, Shigeto Tohma, Kiyoshi Takasugi, Kota Shimada, Akira Murasawa, Shigeru Honjo, Keitaro Matsuo, Hideo Tanaka, Kazuo Tajima, Taku Suzuki, Takuji Iwamoto, Yoshiya Kawamura, Hisashi Tanii, Yuji Okazaki, Tsukasa Sasaki, Peter K Gregersen, Leonid Padyukov, Jane Worthington, Katherine A Siminovitch, Mark Lathrop, Atsuo Taniguchi, Atsushi Takahashi, Katsushi Tokunaga, Michiaki Kubo, Yusuke Nakamura, Naoyuki Kamatani, Tsuneyo Mimori, Robert M Plenge, Hisashi Yamanaka, Shigeki Momohara, Ryo Yamada, Fumihiko Matsuda, Kazuhiko Yamamoto, Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population Nature Genetics. ,vol. 44, pp. 511- 516 ,(2012) , 10.1038/NG.2231
Carolina Hoyo-Becerra, Anastasia Huebener, Martin Trippler, Melanie Lutterbeck, Zijian J. Liu, Kurt Truebner, Thomas Bajanowski, Guido Gerken, Dirk M. Hermann, Joerg F. Schlaak, Concomitant Interferon Alpha Stimulation and TLR3 Activation Induces Neuronal Expression of Depression-Related Genes That Are Elevated in the Brain of Suicidal Persons PLoS ONE. ,vol. 8, pp. e83149- ,(2013) , 10.1371/JOURNAL.PONE.0083149
Byung Lae Park, Lyoung Hyo Kim, Yoo Hyun Choi, June-Hyuk Lee, Taiyoun Rhim, Young Mok Lee, Soo-Taek Uh, Hae-Sim Park, Byoung Whui Choi, Soo-Jong Hong, Choon-Sik Park, Hyoung Doo Shin, Interleukin 3 (IL3) polymorphisms associated with decreased risk of asthma and atopy. Journal of Human Genetics. ,vol. 49, pp. 517- 527 ,(2004) , 10.1007/S10038-004-0184-X
Beatrice Setnik, José N. Nobrega, Long-chain acyl-CoenzymeA synthetase-2 mRNA: increased cerebral cortex expression in an animal model of depression. Progress in Neuro-psychopharmacology & Biological Psychiatry. ,vol. 28, pp. 577- 582 ,(2004) , 10.1016/J.PNPBP.2004.01.014