Bacterial Protein Toxins: Helicobacter pylori mechanisms for inducing epithelial cell proliferation

摘要: Helicobacter pylori , the first bacterium to be designated a Class I carcinogen, has major aetiological role in human gastric carcinogenesis. H. infection is acquired primarily childhood and, majority of instances, and associated chronic gastritis are lifelong. A key feature relevance increased risk developing cancer hyperproliferation epithelial cells induced by bacterium. Infection with cell proliferation both humans experimental animal models. Clinically, there marked diversity outcome only few infected subjects will develop (reviewed Peek Blaser, 2002). Recent studies Japan show that greatest nonulcer dyspesia or ulceration who severe atrophy intestinal metaplasia (Uemura et al., 2001). Bacterial virulence factors such as cag pathogenicity island (PAI) (Blaser 1995; Kuipers Webb 1999) genetic polymorphisms interleukin-1β IL-1 receptor antagonist genes overexpression hypochlorhydria (El-Omar 2000; Machado 2001; Furuta 2002) have each been linked an and/or type cancer. one several infections recently development neoplasia (see Chapter 9).