Mineralocorticoid receptor blockade prevents Western diet-induced diastolic dysfunction in female mice.

摘要: Overnutrition/obesity predisposes individuals, particularly women, to diastolic dysfunction (DD), an independent predictor of future cardiovascular disease. We examined whether low-dose spironolactone (Sp) prevents DD associated with consumption a Western Diet (WD) high in fat, fructose, and sucrose. Female C57BL6J mice were fed WD or without Sp (1 mg·kg−1·day−1). After 4 mo on the WD, exhibited increased body weight visceral but similar blood pressures, compared control diet-fed mice. prevented development WD-induced DD, as indicated by decreased isovolumic relaxation time improvement myocardial performance (