Bacterial nanocellulose as a corneal bandage material: a comparison with amniotic membrane.

摘要: Corneal trauma and ulcerations are leading causes of corneal blindness around the world. These lesions require attentive medical monitoring since improper healing or infection has serious consequences in vision quality life. Amniotic membrane grafts represent common solution to treat severe wounds. However, amniotic membrane's availability remains limited by dependency on donor tissues, its high price short shelf Consequently, there is an active quest for biomaterials injured tissues. Nanocellulose synthetized bacteria (BNC) emergent biopolymer with vast clinical potential skin tissue regeneration. BNC also exhibits appealing characteristics act as alternative bandage such as; liquid holding capacity, biocompatibility, flexibility, natural - but animal free-origin a myriad functionalization opportunities. Here, we present initial study aiming at testing suitability regarding preclinical requirements using benchmark. Bacterial nanocellulose higher mechanical resistance sutures slightly longer stability under vitro ex vivo simulated physiological conditions than membrane. Additionally, bacterial offers good conformability shape eye globe easy manipulation settings. excellent attributes accompanied facts that stable room temperature long periods, can be heat-sterilized produce, reinforce more accessible ocular surface bandage.