Oral prostacyclin enhances the pulmonary vasodilatory effect of nitric oxide in children with pulmonary hypertension
作者： Kei-ichiro Uese , Fukiko Ichida , Shin-ichi Tsubata , Ikuo Hashimoto , Yuji Hamamichi
DOI: 10.1017/S1047951100004340
关键词: Cardiology 、 Internal medicine 、 Pulmonary hypertension 、 Venous blood 、 Medicine 、 Vasodilation 、 Cyclic gmp 、 Cardiac catheterization 、 Nitric oxide 、 Vascular resistance 、 Prostacyclin
摘要: To evaluate the potential efficacy of combined administration inhaled nitric oxide and oral beraprost sodium in producing pulmonary vasodilation, we studied 20 patients with hypertension during cardiac catheterization. We also evaluated some mechanisms vasodilation under these circumstances by investigating levels cyclic GMP AMP venous blood. A significant decrease vascular resistance was observed after (−37 ± 6%, p
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