Intestinal infection results in impaired lung innate immunity to secondary respiratory infection

摘要: Abstract Pneumonia and diarrhea are among the leading causes of death worldwide, epidemiological studies have demonstrated that is associated with an increased risk subsequent pneumonia. Our aim was to determine impact intestinal infection on innate immune responses in lung. Using a mouse model by Salmonella enterica serovar Typhimurium (S. Typhimurium), we investigated how gut compartment can modulate immunity lungs susceptibility bacterial (Klebsiella pneumoniae) challenge. We found alterations frequencies cells intestinally-infected mice compared uninfected mice. On challenge K. pneumoniae prior higher lung burden inflammation, neutrophil margination, extracellular traps (NETs), but lower overall numbers neutrophils, without infection. Together, these results suggest impacts responses, most notably characteristics, potentially resulting secondary Author summary Infections worldwide. Human shown children at How infections not well known. In present study, reveal mucosa may compromise immunity, offering new insights into respiratory infections. upon infection, more moribund despite having burden, they show reduced neutrophils also excessive formation providing evidence pulmonary tissue damage. Collectively, data identify direct link between enteric suggests impair lungs.