Environment-friendly synthesis of nitrogen-containing heterocyclic compounds
作者： M Campanati , A Vaccari , O Piccolo
DOI: 10.1016/S0920-5861(00)00345-X
关键词: Green chemistry 、 Ethylene glycol 、 Quinoline 、 Catalysis 、 Heterogeneous catalysis 、 Pyrrole 、 Space velocity 、 Copper chromite 、 Organic chemistry 、 Chemistry
摘要: Abstract A novel environment-friendly vapour phase synthesis of different classes nitrogen-containing heterocyclic compounds was developed using non-hazardous, commercially available and low cost feeds. 2-Methyl-8-ethylquinoline (MEQUI) obtained from 2-ethylaniline (2-ETAN) ethylene glycol (EG) or chloroethanol (CE), operating at high temperature in the presence acid-treated K10 montmorillonite ZnCl2/K10 montmorillonite. At lower temperatures copper chromite catalysts, 7-ethylindole (7-ETI) 5-ethylindole (5-ETI) were 2-ETAN 4-ethylaniline (4-ETAN), respectively, EG; excess alkylaniline required to avoid formation polyalkylated by-products. Mixing SiO2 with best chromite, made it possible operate higher LHSV values, thus improving yield alkylindoles. Finally, N-(2-ethylphenyl)pyrrole (EPP) N-(2-ethylphenyl)pyrrolidine (EPD) synthesised a commercial catalyst feeding 2,3-dihydrofuran (DHF), EPP being favoured by absence water feed. The reaction pathway for each is proposed, evidence key features catalysts identified.
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