STUDIES OF REPLICATION MECHANISMS WITH THE T4 BACTERIOPHAGE IN VITRO SYSTEM
作者： Bruce M. Alberts , Jack Barry , Pat Bedinger , Rae Lyn Burke , Urszula Hibner
DOI: 10.1016/B978-0-12-048850-6.50045-4
关键词: Genetics 、 Biology 、 Replication factor C 、 Minichromosome maintenance 、 Origin of replication 、 Control of chromosome duplication 、 Eukaryotic DNA replication 、 Origin recognition complex 、 Licensing factor 、 DNA replication
摘要: ABSTRACT. Seven T4 bacteriophage-coded proteins have been purified which are essential for replication fork movement both in vivo and vitro . Experiments reported enable us to assign functions the individual position them at least tentatively fork. The seven assigned one of following four functional classes: helix-destabilizing protein, DNA polymerase, polymerase accessory proteins, RNA priming proteins. Comparison is made with simpler system encoded by bacteriophage T7, more complex E. coli host. We suggest that required organisms larger genomes, due fact a greater accuracy needed their process.
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