Human VDAC isoforms differ in their capability to interact with minocycline and to contribute to its cytoprotective activity.
作者： Andonis Karachitos , Daria Grobys , Monika Antoniewicz , Sylwia Jedut , Joaquin Jordan
DOI: 10.1016/J.MITO.2016.03.004
关键词: Biochemistry 、 Minocycline 、 Cytoprotection 、 Biology 、 Cell 、 Gene isoform 、 Saccharomyces cerevisiae 、 Cell biology 、 Voltage-dependent anion channel 、 Plasma protein binding 、 Mitochondrion
摘要: It has been previously demonstrated that cytoprotective activity displayed by minocycline in the case of yeast Saccharomyces cerevisiae cells pretreated with H2O2 requires presence functional VDAC (YVDAC1). Thus, we decided to transform YVDAC1-depleted (Δpor1 cells) plasmids expressing human isoforms (HVDAC1, HVDAC2, HVDAC3) estimate their involvement effect. We observed only expression HVDAC3 Δpor1 provided minocycline-mediated cytoprotection against although all are cells. The observation appears be important for on-going discussion concerning isoform roles mitochondria and cell functioning.
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