The nature and composition of the internal environment of the developing brain.

摘要: 1. The fetal brain develops within its own environment, which is protected from free exchange of most molecules among extracellular fluid, blood plasma, and cerebrospinal fluid (CSF) by a set mechanisms described collectively as "brain barriers." 2. There are high concentrations proteins in CSF, due not to immaturity the blood-CSF barrier (tight junctions between epithelial cells choroid plexus), but specialized transcellular mechanism that specifically transfers some across plexus immature brain. 3. CSF excluded presence barriers at CSF-brain interfaces on inner outer surfaces. These present adult. 4. Some plasma developing Their may be explained combination specific uptake synthesis situ. 5. Information about composition (electrolytes well proteins) importance for culture conditions used experiments with tissue vitro, neurons exposed relatively only when they have cell surface membrane contact CSF. 6. developmental protein understood involved providing physical force (colloid osmotic pressure) expansion cerebral ventricles during development, possibly having nutritive development functions.