T Cell Response to Preproinsulin I and II in the Nonobese Diabetic Mouse
作者： Philippe Halbout , Jean-Paul Briand , Chantal Bécourt , Sylviane Muller , Christian Boitard
DOI: 10.4049/JIMMUNOL.169.5.2436
关键词: T cell 、 Proinsulin 、 Internal medicine 、 Nod 、 Biology 、 Antigen 、 Endocrinology 、 Epitope mapping 、 Epitope 、 Preproinsulin 、 NOD mice 、 Immunology
摘要: Immunization against insulin, insulin B chain, or chain peptide B(9-23) (preproinsulin II(33-47)) prevents diabetes in the nonobese diabetic (NOD) mouse. Whether not II(33-47) is only proinsulin determinant recognized by CD4 T cells remains unclear. Using two libraries spanning entire sequence of preproinsulin I and II, respectively, we identified specific for four epitopes within islet cell infiltrate prediabetic female NOD mice. These were among immunogenic to which a response was detected after immunization mice with individual peptides CFA. Immunogenic found on both isoforms especially isoform expressed thymus. The autoimmune represented part immune 15-wk-old This first systematic study mouse model.
highwire.org参考文章(46)
J P Briand, J Neimark, Development of a fully automated multichannel peptide synthesizer with integrated TFA cleavage capability. Peptide research. ,vol. 6, pp. 219- 228 ,(1993)
L H Glimcher, C Chan, J A Schroer, E M Shevach, Fine specificity of cloned insulin-specific T cell hybridomas: evidence supporting a role for tertiary conformation. Journal of Immunology. ,vol. 131, pp. 2868- 2874 ,(1983)
J White, M Blackman, J Bill, J Kappler, PPGD Marrack, DP Gold, W Born, None, Two better cell lines for making hybridomas expressing specific T cell receptors. Journal of Immunology. ,vol. 143, pp. 1822- 1825 ,(1989)
F Housseau, N Rouas, D Bellet, J M Bidart, J G Guillet, S Christophe, Influence of protein-quaternary structure on antigen processing. Journal of Immunology. ,vol. 150, pp. 782- 792 ,(1993)
Dana Elias, Hadar Marcus, Tamara Reshef, Vitaly Ablamunits, Irun R. Cohen, Induction of diabetes in standard mice by immunization with the p277 peptide of a 60-kDa heat shock protein. European Journal of Immunology. ,vol. 25, pp. 2851- 2857 ,(1995) , 10.1002/EJI.1830251021
HARTEMANN, RICHARD, BOITARD, Absence of significant Th2 response in diabetes-prone non-obese diabetic (NOD) mice. Clinical and Experimental Immunology. ,vol. 116, pp. 225- 230 ,(1999) , 10.1046/J.1365-2249.1999.00883.X
O. S. Birk, D. C. Douek, D. Elias, K. Takacs, H. Dewchand, S. L. Gur, M. D. Walker, R. van der Zee, I. R. Cohen, D. M. Altmann, A role of Hsp60 in autoimmune diabetes: analysis in a transgenic model. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 1032- 1037 ,(1996) , 10.1073/PNAS.93.3.1032
D. L. Kaufman, R. Tisch, N. Sarvetnick, L. Chatenoud, L. C. Harrison, K. Haskins, A. Quinn, E. Sercarz, B. Singh, M. von Herrath, D. Wegmann, L. Wen, D. Zekzer, Report From the 1st International NOD Mouse T-Cell Workshop and the Follow-Up Mini-Workshop Diabetes. ,vol. 50, pp. 2459- 2463 ,(2001) , 10.2337/DIABETES.50.11.2459
Robert R Latek, Anish Suri, Shirley J Petzold, Christopher A Nelson, Osami Kanagawa, Emil R Unanue, Daved H Fremont, Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice. Immunity. ,vol. 12, pp. 699- 710 ,(2000) , 10.1016/S1074-7613(00)80220-4
Victoria L Heath, Nel C Moore, Sonia M Parnell, Don W Mason, Intrathymic Expression of Genes Involved in Organ Specific Autoimmune Disease Journal of Autoimmunity. ,vol. 11, pp. 309- 318 ,(1998) , 10.1006/JAUT.1998.0210