L-Carnosine Stimulation of Coenzyme Q10 Biosynthesis Promotes Improved Mitochondrial Function and Decreases Hepatic Steatosis in Diabetic Conditions.

摘要: Mitochondrial dysfunction in type 2 diabetes leads to oxidative stress, which drives disease progression and complications. L-carnosine, an endogenous dipeptide, improves metabolic control, wound healing kidney function animal models of diabetes. Coenzyme Q (CoQ), a component the mitochondrial electron transport chain, possesses similar protective effects on We aimed study effect carnosine CoQ, assess any synergistic CoQ improved mouse model Carnosine enhanced gene expression increased hepatic biosynthesis db/db mice, model. Co-administration function, lowered ROS formation reduced signs stress. Our work suggests that exerts beneficial synthesis when combined with cellular redox balance liver diabetic mice. (4) Conclusions: L-carnosine has stress both alone combination obese