Differences in nasopharyngeal bacterial carriage in preschool children from different socio‐economic origins

摘要: A prospective cohort study of preschool healthy children (3-6 years old) from two distinct socio-economic settings in the Brussels area, Belgium, was conducted during 2006-2008. The objectives were to evaluate nasopharyngeal colonization by Streptococcus pneumoniae, Staphylococcus aureus, Moraxella catarrhalis and Haemophilus influenzae at time PCV7 vaccine introduction assess level impact on flora composition antibiotic resistance. Three hundred thirty-three included a total 830 samples collected together with epidemiological data. Pneumococcal serotypes resistance profiles determined. Risk factors for carriage bacterial associations analysed multivariate logistic regression. Carriage rates high all pathogens. Fifty per cent colonized least once S. 69% 67% M. 83% H. influenzae. uptake higher among setting pneumoniae varied accordingly. Children lower schools more likely carry catarrhalis, aureus antibiotic-resistant including proportion non-typeable pneumococcal strains. Positive between Influenza, detected. Our indicates that nasopharynx is influenced not only age but also settings. child's might represent unique dynamic environment modulated intricate interactions species, host immune system immunization.