Systematic review: Impact of meningococcal vaccination on pharyngeal carriage of meningococci.
作者： Stephanie Dellicour , Brian Greenwood
DOI: 10.1111/J.1365-3156.2007.01929.X
关键词: Carriage 、 Immunology 、 Meningococcal vaccine 、 Meningococcal disease 、 Vaccination 、 Polysaccharide Vaccine 、 Serogroup c 、 Medicine 、 MENINGOCOCCAL POLYSACCHARIDE 、 Conjugate vaccine 、 Internal medicine
摘要: OBJECTIVE To investigate the effect of meningococcal vaccines on pharyngeal carriage meningococci. METHODS Systematic review. MEDLINE and EMBASE were searched for relevant studies. Controlled trials observational studies which used comparison groups or compared rates before after vaccination included in RESULTS Twenty-nine satisfied inclusion criteria. Twenty-five reported a polysaccharide vaccine, one serogroup C conjugate vaccine three impact B outer-membrane overall and/or serogroup-specific rates. Ten found reduced carriage; seven these focussed high-risk had short follow-up period. Only five civilian populations Africa showed significantly carriage. Many methodological shortcomings. The study assessed significant impact. Three protein no CONCLUSIONS A few well-designed have been undertaken. Such should be an essential component evaluation new vaccines, particularly those introduced to control epidemic disease Africa.
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