Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases

摘要: The clinical and pathological features of 150 cases ovarian small cell carcinoma the hypercalcemic type are described. patients ranged from 9 to 43 (average 23.9) years age. serum calcium level was known be elevated in 49 79 (62%) whose preoperative levels were measured. Four these had symptoms hypercalcemia, one them undergone neck exploration with negative results before tumor discovered. At laparotomy unilateral 148 (99%). Extraovarian spread present approximately half cases. tumors 6 26 15.3) cm greatest dimension. Microscopic examination disclosed various patterns, most common which diffuse sheets cells punctured by variable numbers follicle-like spaces; also grew nests, cords, clusters, singly. spaces, 80% cases, contained fluid that almost always eosinophilic rarely basophilic. Glands or cysts lined mucinous epithelial 12% neoplasms. neoplastic typically round hyperchromatic nuclei brisk mitotic activity. Fifty percent tumors, however, a component moderate abundant amounts cytoplasm, sometimes large hyaline globules paler more prominent nucleoli than cells. Immunohistochemical staining confirmed nature as did electron microscopy, characteristically showed dilated rough endoplasmic reticulum. Five seven investigated immunohistochemical for parathyroid hormone-related protein positive results. All 23 examined flow cytometry interpretable diploid. Fourteen 42 (33%) stage IA disease whom follow-up information is available remained well free 1-13 5.7) postsurgery; died their disease, usually within 2 years; five recurrences but alive at last follow-up. Almost all higher patient IIB who received intensive chemotherapy radiation therapy apparently 7 years. Features appeared associated favorable outcome included an age > 30 years, normal determination, size < 10 cm, absence cells.(ABSTRACT TRUNCATED AT 400 WORDS)