Modeling Development and Disease with Organoids
作者： Hans Clevers
DOI: 10.1016/J.CELL.2016.05.082
关键词: Physiology 、 Organ Specificity 、 Neuroscience 、 Genetic enhancement 、 Single-cell analysis 、 Regenerative medicine 、 Embryonic stem cell 、 Stem cell 、 Biology 、 Organoid 、 Disease
摘要: Recent advances in 3D culture technology allow embryonic and adult mammalian stem cells to exhibit their remarkable self-organizing properties, and the resulting organoids reflect key structural and functional properties of organs such as kidney, lung, gut, brain and retina. Organoid technology can therefore be used to model human organ development and various human pathologies 'in a dish.” Additionally, patient-derived organoids hold promise to predict drug response in a personalized fashion. Organoids open up new avenues for …
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