Complement activation and hemodynamic changes following intravenous administration of phosphorothioate oligonucleotides in the monkey.
作者： WAYNE M. GALBRAITH , WILLIAM C. HOBSON , PATRICIA C. GICLAS , PAUL J. SCHECHTER , SUDHIR AGRAWAL
关键词: Hemoconcentration 、 Immunology 、 Peripheral 、 Complement system 、 Phosphorothioate Oligonucleotides 、 Chemistry 、 Oligonucleotide 、 Hemodynamics 、 Phosphorothioate Oligonucleotide 、 Pharmacology 、 Blood pressure
摘要: Rapid intravenous infusion of GEM 91, a 25-mer phosphorothioate oligonucleotide complementary to the gag site of HIV, in the monkey produces transient decreases in peripheral total …
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