Application of two methods to determine killing of Streptococcus pneumoniae by various fluoroquinolones.
作者： J.M. Blondeau , L.D. Blondeau , C. Hesje , S. Borsos
DOI: 10.1179/JOC.2006.18.4.366
关键词: Gemifloxacin 、 Streptococcus pneumoniae 、 Biology 、 Colony-forming unit 、 Moxifloxacin 、 Streptococcaceae 、 Gatifloxacin 、 Microbiology 、 Antibacterial agent 、 Levofloxacin
摘要: AbstractMinimum inhibitory concentration (MIC) testing measures the lowest drug that prevents microbial growth using an inoculum of 105 colony forming units/ml (cfu/ml) whereas mutant prevention (MPC) (inoculum ≍1010 cells) defines antimicrobial threshold would require organism to possess two simultaneous mutations for continued in presence drug. The rates at which multidrug-resistant Streptococcus pneumoniae [MDRSP] were killed by respiratory fluoroquinolones, gatifloxacin, gemfloxacin, levofloxacin and moxifloxacin, compared based on MIC MPC concentrations inocula ranging from 106-109 cfu/ml. failed eradicate all viable cells resulted 99.9% 100% cellular reduction following 12-24 hours exposure. values against S. different each fluoroquinolone. selection ...
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