Reduction in circulating markers of endothelial dysfunction in HIV-infected patients during antiretroviral therapy.

摘要: Objectives Antiretroviral therapy (ART) in HIV-infected patients is associated with increased cardiovascular risk. Circulating markers of endothelial dysfunction may be used to study early atherogenesis. The aim our was investigate changes such during initiation ART. Methods In 115 HIV-positive treatment-naive patients, plasma lipids, E-selectin, soluble intercellular adhesion molecule 1 (sICAM-1), vascular cell (sVCAM-1), tissue-type plasminogen activator inhibitor (tPAI-1) and high-sensitivity C-reactive protein (hsCRP) were measured before after 2 14 months ART. A control group 30 healthy subjects included. Values are mean±standard error the mean. Results Prior treatment, had elevated levels sICAM-1 (296±24 vs. 144±12 ng/mL), tPAI-1 (18 473±1399 5490±576 pg/mL) hsCRP (28 060±5530 6665±2063 ng/mL) compared controls (P<0.001). In contrast, sVCAM-1 E-selectin did not differ between groups. Initiation ART resulted significantly lower (15.1±0.8; P<0.01), (248±12 ng/mL; P<0.05), (766±33 ng/mL; P<0.001) (14 708±2358 ng/mL; months, which remained reduced at months. influenced by ART. Conclusions Markers related HIV RNA viral load. majority these markers. positive effect dependent on duration infection prior treatment.