Apelin Attenuates Hyperoxic Lung and Heart Injury in Neonatal Rats
作者： Yvonne P. de Visser , Frans J. Walther , El Houari Laghmani , Arnoud van der Laarse , Gerry T. M. Wagenaar
DOI: 10.1164/RCCM.200909-1361OC
关键词: Intensive care 、 Apelin receptor 、 Bronchopulmonary dysplasia 、 Apelin 、 Internal medicine 、 Hyperoxia 、 Lung 、 Endocrinology 、 Medicine 、 Nitric oxide synthase 、 Lung injury
摘要: Rationale: Apelin, a potent vasodilator and angiogenic factor, may be novel therapeutic agent in neonatal chronic lung disease, including bronchopulmonary dysplasia.Objectives: To determine the beneficial effect of apelin rats with hyperoxia-induced injury, model for premature infants dysplasia.Methods: The cardiopulmonary effects treatment (62 μg/kg/d) were studied by exposure to 100% oxygen, using two strategies: early concurrent during continuous hyperoxia 10 days late recovery which was started on Day 6 after hyperoxic injury 9 continued 9-day period. We investigated both models role nitric oxide–cyclic guanosine monophosphate (cGMP) pathway specific inhibition oxide synthase activity Nω-nitro-l-arginine methyl ester (l-NAME, 25 mg/kg/d).Measurements Main Results: Parameters ...
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