The Chronobiologic Pilot Study with Special Reference to Cancer Research is Chronobiology or, rather, its Neglect Wasteful?

摘要: It is customary in biologic and, particular, medical research to do a pilot study first. Statements such as ‘... undertook the evaluate methodology for conducting main study. The was not designed yield definitive results, but figures are suggestive’ (22) and often found literature. Such pilots indispensable order ascertain that given chemical or method ‘works’. ‘Work’ may also mean an anticipated effect found. If timing enters protocol, it usually form of suggestion be carried out at one convenient timepoint. encouraging, cancer other research, by testing, instance, new drug, ‘definitive’ approach practiced. A treatment compared with old one. Usually, therapeutic arms specified dose, hardly ever respect circadian rhythm stage. chronobiologic assessment drug considered. ‘pilot’ negative, no longer pursued.