Genetic Regulation of Neuronal Progranulin Reveals a Critical Role for the Autophagy-Lysosome Pathway
作者： Lisa P. Elia , Amanda R. Mason , Amela Alijagic , Steven Finkbeiner
DOI: 10.1523/JNEUROSCI.3498-17.2019
关键词: Neuron 、 Loss function 、 Frontotemporal lobar degeneration 、 Autophagy 、 Haploinsufficiency 、 Lysosome 、 Neuronal ceroid lipofuscinosis 、 Cell biology 、 Phenotype 、 Biology
摘要: … We first designed and developed an ELISA to detect extracellular mouse progranulin … RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing …
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