Low dose decitabine in very high risk relapsed or refractory acute myeloid leukaemia in children and young adults
作者： Christine L. Phillips , Stella M. Davies , Richard McMasters , Michael Absalon , Maureen O'Brien
DOI: 10.1111/BJH.12268
关键词: Myeloid 、 Refractory 、 Salvage therapy 、 Leukemia 、 Oncology 、 Decitabine 、 Medicine 、 Transplantation 、 Internal medicine 、 Tolerability 、 Immunology 、 Young adult
摘要: Low-dose decitabine has encouraging activity and tolerability in adults with acute myeloid leukaemia (AML), but paediatric experience is lacking. We report our retrospective eight children young (median age 4 years) refractory/relapsed AML, who had failed multiple regimens or were not candidates for standard retrieval due to prior toxicities. Three of patients (38%) complete response (CR; 1 each CR, CR incomplete platelet recovery count recovery). Best responses observed after a median 2.5 cycles (range 1-4 cycles). Four received subsequent allogeneic stem cell transplant, two remain long-term CR.
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